This series includes material from the broad scope of Antonucci's professional design career. Antonucci worked as a freelance designer throughout the entirety of his life and career, focusing primarily on corporate, not-for-profit organization, book, and magazine design. The bulk of the series is divided into corporate design, on the one hand, and book and magazine design, on the other.

Antonucci's corporate and not-for-profit design clients consisted primarily of organizations based in the New York City metropolitan area. Among the clients documented here include the Four Seasons hotel, the New York State Pavilion, Parsons School of Design, Carnegie Hall, and Lincoln Center. Also found in this section are Antonucci's designs for the City of New York, including neighborhood and district logos, information kiosks, maps, and other signage.

Of additional note amongst these materials is Antonucci's work with the Mead paper company's Mead Library of Ideas, located in the Pan Am Building (now MetLife Building) in midtown Manhattan, for whom he designed catalogs, but which also featured an exhibition and catalog featuring Antonucci's work.

Book and magazine design clients were primarily progressive Catholic magazines and publishers. Antonucci provided cover and interior design, as well as illustrations, to such magazines as Commonweal and Church, as well as numerous parish publications. Among the secular publications he did work for were the New York Times Book Review and Fortune magazine.

Also of note in this series are Antonucci's building and interior design work for both St. Thomas of Canterbury church in Cornwall-on-Hudson, NY, and the Congregation Beth Tora synagogue in Brooklyn.